ea0022p170 | Cardiovascular endocrinology and lipid metabolism | ECE2010
Mustafina Svetlana
, Rymar Oksana
, Simonova Galina
, Malyutina Sofia
, Nikitin Yuri
We previously have reported that short-term treatment of mice with recombinant hGH leads to significant increases in bodyweight (BW), lean body mass (LBM) and liver weight, but unlike in humans does not robustly increase circulating levels of IGF1. We now tested the hypothesis that formation of neutralizing antibodies in mice treated with rhGH could explain the lack of IGF1 response. Therefore, we intentionally induced antibody formation against hGH in female FVB...